Volcano plot of the two-sided two-sample t -test comparison of 3'-ETS digested versus undigested TREX samples ( n = 4 biological replicates), showing the enrichment of EXOSC4 and several known RBFs, along with RPS17, RPS25, RPL23A and RPL17. Curved lines in all volcano plots mark the significance boundary (FDR = 0.05, S0 = 0.1).