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Depiction of the SABRE hyperpolarization process whereby an iridium precatalyst,1, is reacted with a substrate and H2to form a typical SABRE catalyst of the form [Ir(H)2(IMes)(NSub)3]Cl where NSub is an N-donor substrate. The SABRE effect is observed when the complex undergoes reversible exchange of both parahydrogen and substrate. In this work, NSub is 3,5-dichloropyridine (A) or 3,5-dibromopyridine (B).

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