Molecular dynamics simulation of the dopamine aptamer in the absence and presence of the target analyte revealed an elongation of the serotonin aptamer and a compression of the dopamine aptamer. White arrows indicate the analyte binding pocket. Divergent structure-switching behavior explains the opposite trends in biosensor behavior between serotonin and dopamine aptamers. Panels b, e, f adapted with permission from ref(44). Copyright 2023 American Chemical Society.
