Levels of the CSF tau STA and t-tau ratio in a well-characterized cohort with paired antemortem CSF samples and neuropathological diagnosis at postmortem (cohort 3). The groups diagnosed with ADNC ( n = 21) and those with ADNC plus concomitant neurodegenerative pathologies (ADNC + other, n = 19) each had significantly lower levels of the STA and t-tau ratio versus those with low tau pathology (probably age-related tau, n = 8) and non-ADNC (other pathology, n = 19). In the box plots, the center line represents the median, the boundaries of the box are the 25th and 75th percentiles, and the whiskers extend to the furthest data value 1.5 times the interquartile range (IQR). The displayed P values correspond to post hoc pairwise MannWhitney U -tests with BenjaminiHochberg false discovery rate (FDR) multiple comparison adjustment, after a significant overall KruskalWallis rank-sum test (chi-squared = 17.3, d.f. = 3, P = 6.1 10 -4 ).
