CSF STA and t-tau ratio levels according to diagnostic group in the tau-PET cohort (cohort 4). The STA and t-tau ratio was lowest in tau-PET + AD dementia/T + ( n = 17) and highest in tau-PET young adults (young, n = 25), and tau-PET older adults either with CN/T ( n = 92) or MCI/T ( n = 30). Tau-PET + individuals with MCI/T ( n = 16) and tau-PET AD/T ( n = 6) showed intermediate values. As above, the center of the box plot indicates the median, the box boundaries indicate the 25th and 75th percentiles, and the whiskers indicate the furthest value 1.5 times the IQR. The P values correspond to post hoc pairwise MannWhitney U -tests with FDR adjustment, after a significant overall KruskalWallis rank-sum test (chi-squared = 41.8, d.f. = 5, P = 6.4 10 -8 ).
