Incubation with the STA core peptide resulted in a significant depolarization of the RMP (mean RMP in slices incubated with the STA core of -58 1.31 mV -1 ( n = 12) compared with -65 0.83 mV -1 in controls ( n = 12)); Kruskal–Wallis test (Kruskal–Wallis statistic = 14.27, P = 0.0065) with Dunn’s multiple comparisons ( P = 0.0400), which was not observed with the other tau truncations. Data are presented as the mean s.e.m., with individual data points overlaid. RMP depolarization with the STA core also significantly differed from that of the C-terminal peptide.
