Bar Plot from Scientific Research

Incubation with the STA core peptide significantly increased the FR (a correlate of neuronal excitability). The mean FR in slices incubated with the STA core was 6.4 0.85 Hz ( n = 12), compared to the mean FR in aCSF control slices of 2.7 0.32 Hz ( n = 12); Kruskal–Wallis test (Kruskal–Wallis statistic = 25.66, P < 0.0001) with Dunn’s multiple comparisons ( P = 0.0016). Incubation with the fibril core also significantly increased the FR compared to aCSF controls (mean FR in slices incubated with the fibril core was increased to 6.3 0.62 Hz ( n = 12); Kruskal–Wallis test with Dunn’s multiple comparisons ( P = 0.0006). No change versus aCSF control was observed with N-terminal or C-terminal tau. Data are presented as the mean s.e.m., with individual data points overlaid.

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