Inset to i : representative example traces of fEPSP waveforms for the 100-ms interval for each tau peptide. The first fEPSPs were normalized so that facilitation could be compared across conditions. * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001. P values for between-group comparisons have been provided in Supplementary Table 3 . To summarize, the results demonstrate that the recombinant STA core region peptide has a strong in vitro aggregation propensity and robust impairment of neuronal excitability and functional modulation of neuronal and network functions in mouse hippocampal slices.
