The hierarchical clustering heatmap of metabolites identified in PN/MES cells and their sEVs. Distance measure: Euclidean, Clustering algorithm: Ward. The metabolomics data were normalized by sum. The heatmap shows the class averages. Green: proneural cells (PN_Cells); purple: mesenchymal cells (MES_Cells); light green: proneural small extracellular vesicles (PN_sEVs); light purple: mesenchymal small extracellular vesicles (MES_sEVs). Metabolites detected in at least three out of the five replicates for both parental cell lines of a given subtype and/or in at least two out of the three replicates for both sEV samples of a given subtype are indicated in the heatmap.
