Comparison of the tau-FRET signal in neuropathologically diagnosed AD, other neurodegenerative diseases (progressive supranuclear palsy, corticobasal degeneration and PiD) and controls (cohort 1: n = 10 participants per group) with a KruskalWallis test with Dunns multiple comparisons. Cohort 2 includes neuropathologically diagnosed individuals with AD and controls ( n = 4 participants each); two-sided MannWhitney U -test = 0 ( P = 0.0286). In each panel, data points are shown as the mean s.e.m. The boxplot center indicates the median, the box boundaries indicate the 25th and 75th percentiles, and the whiskers indicate extreme values outside the box boundaries (Q1 1.5 IQR and Q3 + 1.5 IQR), where Q1, Q3 and IQR refer to the 25th percentile, 75th percentile and interquartile range, respectively.
