Scatter Plot from Scientific Research

Comprehensive analysis of scRNA-seq data obtained from primary prostate fibroblasts co-cultured with T-ERG and PRN epithelial cells. The UMAP plot on the left illustrates fibroblasts clustering, with each group annotated based on their genotypic identity indicating their co-culture conditions: T-ERG ( n = 10529 cells), PRN ( n = 7535 cells), or control group ( n = 6921 cells). The UMAP plot on the right shows the fibroblast populations annotated according to their transcriptional similarities to the stromal subtypes identified in the scRNA-seq analysis of prostate tissues: c0 ( n = 27), c1 ( n = 8182), c2 ( n = 19), c3 ( n = 9327), c4 ( n = 7), c5 ( n = 8), c6 ( n = 1066), and c7 ( n = 6349). CAFs: cancer-associated fibroblasts; H&E: hematoxylin & eosin staining; IF: immunofluorescence; NEPC: neuroendocrine prostate cancer; UMAP: Uniform Manifold Approximation and Projection; WT: wild type.

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