Venn Diagram from Scientific Research

Venn diagram showing the overlap between the 1027 NMD targets defined using mouse N2A neuroblastoma cells [ 33 ], and the 5733 FMRP targets defined using total mouse cerebral cortex [ 77 ], mouse hippocampus [ 77 ], mouse cerebellum [ 77 ], mouse hippocampal CA1 pyramidal neurons [ 78 ], mouse cerebellar granule cells [ 78 ], or mouse whole brain polysome fractions [ 79 ]. The statistical significance of the overlap between NMD targets and CLIP-FMRP targets , i.e., NMD + CLIP-FMRP targets , in the pool of 21,565 protein-coding genes derived from the mouse GENCODE M32 database ( https://www.gencodegenes.org/ ) was calculated using Fisher’s exact test ( P < 2.2 x 10. -16 , odds ratio = 3.26, 95% confidence interval 2.87–3.71) in R version 3.6.3 [ 82 ].

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