Microscopy from Scientific Research

Heart and liver abnormalities in Dscc1 -/- E14.5 mouse embryos. The axial section (left; dorsal to the top) and sagittal re-sections (right; ventral to the top) were obtained through high-resolution episcopic microscopy (HREM) analysis of a Dscc1 -mutant (bottom) and a WT (top) embryo. Bottom left, a ventricular septal defect (vsd) in a Dscc1 -/- embryo. Bottom right, abnormal liver texture, specifically, a cyst (white asterisk) and abnormally enlarged liver sinusoids combined with a reduced number of hepatocytes (black asterisk) in the liver lobe of a Dscc1 -/- embryo. di, diaphragm; e, oesophagus; li, liver; LV, left ventricle; RA, right atrial appendix; RV, right ventricle; VS, ventricle septum. Scale bars, 1 mm. Three embryos per genotype were analysed.

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