Immunofluorescence staining and quantification of Ki67 ( j ), CA9 ( k ), CD31 ( l ) and caspase-3 ( m ) in tumor cryosections (n = 45 sections per treatment). White scale bars on the bottom right represent 10 µm (CA9, CD31, caspase 3) or 20 µm (Ki67 and CA9 DOR-Ucp1 ). All statistical tests were carried out using a two-tailed t -test and data are represented as mean s.d. * P 0.05; ** P 0.01; *** P 0.001.
