Whole-mount wild-type mouse optic nerve sheaths stained for LYVE1, CD31, PROX1 and VEGFR3. The images at the bottom show a higher-magnification view of the area highlighted in the merged image at the top right. Scale bars, 50 m ( a , top left; c , bottom merged), 500 m ( a , top right; c , top merged), 1,000 m ( a , bottom left and right) and 3,000 m ( b ).