From top to bottom. Top Two: Spatial heatmaps of SPP1 and CD74 confirm differential expression of marker genes in the region of the tissue containing tumor and hepatocytes respectively. Bottom: Differential spatial colocalization plots of macrophages near tumor and macrophages near hepatocytes. Larger values shown in red correspond to regions that contain macrophages near tumor and smaller values shown in blue correspond to regions that contain macrophages near hepatocytes. Regions in yellow correspond to regions with no macrophages or regions with macrophages that have a similar amount of tumor cells and hepatocytes in their effective niche.
