From top to bottom. Top Two: Feature plot of module scores for the set of niche-DE tumor-associated macrophage markers finds enrichment in the region of the UMAP corresponding to lipid-associated macrophages. Feature plot of module scores for the set of niche-DE normal macrophage markers finds depletion in the region of the UMAP corresponding to lipid-associated macrophages. Bottom: UMAP of scrna-seq from Wu et al. [ 40 ]. Cells were filtered to only include macrophages, monocytes, and dendritic cells.
