Diff-CRE bQTL matching direction enrichment test results for diff-CREs defined by each displayed score type are plotted as Fisher’s exact test odds ratios with error bars representing the lower bound of the 95% confidence interval. Separate tests were performed on all diff-CRE bQTL (black) and those in the top 5% of F ST values among all variants in CREs genome-wide (purple). Since these are one-sided tests, the upper bound (infinity) is not shown. The total number of CREs used in each test is shown to the right of each odds ratio with asterisks indicating if the P -value passed multiple test correction (*, **, ***, and **** for Bonferroni-corrected P -value < 0.05, 0.005, 5x10 −4 , and 5x10 −5 , respectively)