Illustration from Scientific Research

From left to right: Chromatin accessibility, activity, and contact frequency were assayed in LCLs from four African populations (blue) and four European populations (orange). Enhancer-gene pairs were defined using ABC scores and ATAC, ChIP, and HiC score components quantified. Enhancer-gene pair 1 exemplifies evidence of directional selection (low within- and high between-continental ancestry score variance).

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