(Top) Boxplots of the inferred transcriptional kinetics for enhancer-paired DV genes partitioned into classes based on whether they have a significant kinetic change in burst frequency ( n = 8), size ( n = 16), or both ( n = 5) between the active and inactive clusters (see also Additional file 1 : Fig. S8h). (Bottom) For each class, the log 2 fold change (active/inactive tissues) is plotted. Significant differences (Wilcoxon rank-sum test) are indicated by asterisks, * = P < 0.05, ** = P < 0.01, *** = P < 0.001.