Principle of a 2:4 binary decoder with two input (IN) and four output (OUT) signals and the different input/output combinations (upper panel). The addition of novobiocin (Novo, IN1) and EDTA (IN2) serve as input. The four different output states are represented by the release of distinct proteases, none (OUT 0), TEV protease (OUT A), TVMV protease (OUT B), or Casp3 protease (OUT C). The different proteases are introduced in the material modules A, B, C (lower panel).
