Validation of C with experimental data. mRNA (left) and protein (right) abundance data were extracted from ref. 16 and labelled as neurite-enriched (filled boxes) or somata-enriched (empty boxes) based on their mRNA enrichment (see Methods; mRNA: N s o m a t a = 5623, N n e u r i t e = 1406, p = 0; protein: N s o m a t a = 852, N n e u r i t e = 622, p = 5.12 10 −21 ). Synthetic protein species use their respective energetically cheapest localisation pathway in A, B. Boxplots indicate median, quartiles and 1.5x interquartile ranges. **** p < 0.0001, two-sided Wilcoxon ranksum test.
