Finite element simulations of PMNs (8.5 m in diameter) transmigrating through the restrictive AJs. A cross-sectional view of coupled finite element and boundary element simulations of predicted tension and pressure on PMN plasma membrane during passage through a pore with diameter of 2.4 m under external force of 1.8 nN, which is about 5 times the minimal external force required to push the PMN through the pore. The color maps show color-coded ranges for PMN membrane tension and pressure.