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The integral ER membrane protein protrudin assembles at a tripartite ER-endosome-microtubule interface through its multiple interaction surfaces. Protrudin contains FYVE and LCR domains to bind to the endosome, a kinesin binding domain (KBD), and an FFAT domain that could allow it to bind VAP. In doing so, protrudin integrates the trafficking of endosomes and the ER together along microtubules.

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