Scheme summarizing the three H3K27me3 states at XIST-enriched regions on chrX from (H) and autosomes from (L) and correspondence between X and autosome results. Left: no H3K27me3 in male and female cells; middle: XIST-dependent H3K27me3 deposition in female cells; right: XIST-independent H3K27me3 in male and female cells.