Cell viability of MM099 cell cultures exposed for 48 h to BET (ARV-771 25 nM), BRAF, and MEK inhibitors (dabrafenib 20 nM, trametinib 4 nM), siTCF4, si CTRL, or a combination thereof. Mean and SEM are shown (n = 3 technical replicates, Tukey’s multiple comparison test,*adjusted p < 0.01,***adjusted p < 0.0001).