Selected pathways found significantly enriched or depleted (NES > 1.5 or < −1.5; FDR < 0.25) by GSEA in malignant cells flow-sorted from PDAC organoid-derived co-transplantation mouse models with EgfrKO PSCs (n = 5) compared to PDAC organoid-derived co-transplantation mouse models with EgfrWT PSCs (n = 5).