SHLs on one half of a nucleosome represented as an elongated wedge. In the core nucleosome, DNA interacts with histones H3 and H4, while DNA at the periphery interacts with histones H2A and H2B, and DNA near the entry/exit site interacts with histone H3. The colored gradient shows increasing likelihood of DNA exposure toward the nucleosomal edges due to transient unpeeling. Red circles show locations of TFs binding to nucleosomal DNA, as determined by structural studies discussed in the text.
