Illustration from Scientific Research

FXN activates Fe-S cluster formation, which can be utilized to support (i) mitochondrial bioenergetics via formation of the electron transport chain (ETC) or (ii) cell growth and division. METTL17 is a key Fe-S cluster bearing modulator of mitochondrial bioenergetics, and its absence in FXN-depleted cells accounts for much of the mito. bioenergetic defects observed in these cells. All bar plots show mean ± SD.**p < 0.01,****p < 0.0001. Two-way ANOVA with Bonferroni’s post-test. See alsoFigure S7.

DOI