Microscopy from Scientific Research

Classification of islets from AdarKO mice according to the extent of inflammatory infiltrates as assessed by immunostaining for insulin ( cells), GFP (mutant cells), and CD45 (immune cells). Islets from AdarHET, AdarKO, and AdarKO; Ifih1 mice were scored 7 days (n = 4 for each genotype) and 12 days after tamoxifen injection (AdarHET [n = 7], AdarKO [n = 13], AdarKO; Ifih1 [n = 4]). At least 100 islets from 5 different slides (80 m apart) were scored for each mouse. Each dot represents the score for a single mouse. Student’s unpaired two-tailed t test; error bars indicate mean SEM.*p < 0.01;****p < 0.0001. Scale bars, 20 m.

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