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ADAR1 knockdown in human islets induces ISG expression. RNA isolated from human pseudoislets (n = 11 donors) transduced with either ADAR1 shRNA or scramble shRNA pseudoislets was assessed for expression of ADAR1 (G) and interferon-stimulated genes (H) by RT-PCR, with normalization to scramble shRNA samples.*p < 0.05;**p < 0.01;***p < 0.001.

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