Workflow from Scientific Research

Overview of the different fates of MDVs discovered today. MDVs can deliver protein cargoes to peroxisomes or contribute to the de novobiogenesis of peroxisomes by fusing with specific ER-derived vesicles containing peroxisomal proteins (left). The major transport route delivers MDVs from mitochondria to the endolysosomal system (right). Within the endolysosomal pathway, MDVs can modulate the bacterial defense of the cell and contribute to quality control through lysosomal degradation as well as signaling pathways for example by release of mitochondrial content through exosomes or extracellular vesicles.

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