Protein Structure from Scientific Research

Open access visualization of Protein Structure, Chemical Structure, Active Site, ATP-Bound Inactive LRRK2, Ponatinib-Bound LRRK2
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DOI: 10.1038/s41421-023-00639-8

DOI

Comparison of the active site between ATP-bound inactive LRRK2 and the ponatinib-bound LRRK2. Differences between the Gly loop, C helix, K1906-E1920 salt bridge, Y2018 configuration, and activation loop are indicated. Ponatinib is shown as a yellow surface.

#Protein Structure#Chemical Structure#Active Site#ATP-Bound Inactive LRRK2#Ponatinib-Bound LRRK2#Gly Loop#Alpha-C Helix#K1906-E1920 Salt Bridge#Y2018 Configuration#Activation Loop#Ponatinib

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