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Conceptual illustration showing the general principle of synthetic lethality. The up and down arrows associated with the genes represent different states, for example, mutated/non-mutated. Genetic features are synthetically lethal if the cell viability is affected when they both take on a particular state in the cell. Here, this is represented by the up arrows. The right part of the panel shows how DLVPM can be used to uncover new genetic vulnerabilities using this principle. DLVs are constructed from the sequencing data, and are used to predict susceptibility to gene knockout. Panel b created with BioRender.com.

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