Line Plot from Scientific Research

Force-extension curves of talin alone (no VD1) and in the presence of vinculin VD1 (cycles 1-3) 22 . Binding of vinculin VD1 to force-unfolded talin domains prevents their refolding, increasing talin extension in the 5-10 pN range by almost threefold, thereby softening talin. Vcl, vinculin. Panel g adapted from ref. 22 under a Creative Commons license CC BY 4.0 .

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