Line Plot from Scientific Research

Stability diagram of cell-adhesion complexes. Solid curves (black, red and blue) show bifurcations that lead to the formation of a bistability region (red area) and a biphase–monophase boundary (green dotted curve), which affect the mechanosensitive behaviour of cell adhesion (‘Steady-state behaviour and bifurcation of the clutch system’). The insets around the bistability region illustrate representative cell traction curves within each domain. It is evident that increasing the stiffness of the intracellular part of molecular clutches ( k c ) changes the shape of the cell traction curve, shifting cells from the soft-clutch behaviour of MEF WT cells to the rigid-clutch behaviour of MEF Talin 1 KO, Talin 2 shRNA cells.

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