Bar Plot from Scientific Research

Validation of AllChAT on the gene pair TMTC1 as a passenger of the amplified oncogene KRAS, in primary cell cultures derived from patient tumors CRUK0977 and CRUK0577, and from a non-tumor-tissue-derived primary cell culture from patient CRUK0667. The CN for each locus is indicated numerically. The repressive histone mark H3K27me3 to identify closed chromatin (red), and the active histone mark H3K4me3 to identify open chromatin H3K4me3 (green), were extracted from the Integrative Genomics Viewer and illustrated using BioRender. The intensity of both histone marks was normalized according to the CN. Assessment of DNA methylation status in the promoter region of each gene was performed using the non-tumor PDC as a control for the two tumor PDCs.

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