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Candidate causal proteins were identified through population-matched integration of brain proteomes and GWASs using PWASs and SMR/HEIDI. Each gene is plotted as a circle, with the color denoting an enriched process (gray indicates genes not in an enriched gene set). Solid lines connecting the genes denote evidence of PPI. For Alzheimer’s disease, 64 causal proteins were identified. Of these, 29 had evidence of PPIs among themselves, and there was gene set enrichment for endosomal proteins (FDR < 0.05). Full results are provided in Supplementary Tables 18 and 19.

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