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Candidate causal proteins were identified through population-matched integration of brain proteomes and GWASs using PWASs and SMR/HEIDI. Each gene is plotted as a circle, with the color denoting an enriched process (gray indicates genes not in an enriched gene set). Solid lines connecting the genes denote evidence of PPI. For anxiety symptoms, ten causal proteins were identified, and seven had PPIs with each other. Some of these anxiety causal proteins were enriched in cellular components of the cytoplasmic region, dendritic tree, somatodendritic neuron projection, synapse and glutamatergic synapse (FDR < 0.05). Full results are provided in Supplementary Tables 18 and 19.

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