Microscopy from Scientific Research

Lungs were taken from naive or C57BL/6 mice infected with influenza A virus (IAV) 30–40 days previously, with representative images from mice from two independent experiments shown. Areas of infected lungs with no inflammation have Spib negative airways, while Spib (black arrows) is localized in areas of inflammation (dark red color, indicated by white star) within the lung and in airways; adjacent images showing areas of no inflammation and inflammation show lungs from the same mouse. Data are from 4 to 6 mice per experimental group, combined from two independent experiments. Each symbol represents a lobe from a mouse, with each mouse only represented once in each column, and bars show the median with the interquartile range, as data are not normally distributed. Data analyzed using Kruskal–Wallis with Dunn’s post hoc comparison test.

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