Network from Scientific Research

Summary of genome sequencing analysis performed in zebrafish ( D. rerio ) and cavefish ( P. andruzzii ) with the 6-4phr haplotypes represented in a network. The size of the circles is proportional to the haplotype frequency in the dataset. Coding-region mutations separating haplotypes are marked in the figure and indicated by their position in the coding sequence (CDS). Mutations causing premature stop codons are indicated in red while nonsynonymous mutations are indicated in bold. All 6-4phr haplotypes in the shaded area encode for C-terminally truncated proteins. Reference numbers refer to the zebrafish CDS (dark-grey circle; accession number: 6-4phr NM_131788.1). Total number of sites analyzed: 6-4phr 1562 bp. AA amino acids. The origin of the individual P. andruzzii fish used in this sequence analysis is summarized in Supplementary Table 1 . The 6-4phr sequences have been submitted to GenBank (Accession numbers for P. andruzzii 6-4phr (PV983310, PV983311, PV983312 and PV983313)). Created in BioRender. Foulkes, N. (2025) https://BioRender.com/1osqe99 .

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