Line Plot from Scientific Research

Cumulative distribution plots of inter-spike intervals (ISIs) obtained from whole-cell voltage-clamp recordings of MSN sEPSCs. Recordings were carried out in slices from WT and zQ175 mice after a 1-month treatment with control IgG or the C1q function-blocking antibody (Black = Control IgG, Orange = C1q function-blocking antibody). Bar charts show average frequency (Hz) per cell recorded across conditions. n = 23 cells from 7 mice for WT Ctrl IgG; n = 17 cells from 7 mice for WT C1q Blk Ab; n = 14 cells from 4 mice for zQ175 Ctrl IgG; and n = 23 cells from 7 mice for zQ175 C1q Blk Ab. For the cumulative distribution plots for WT, P = 0.00078, and for zQ175, P = 0.00015.

DOI