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Quantification of corticostriatal synapses (co-localized VGLUT1 and Homer1 puncta) in the caudate nucleus of control, Vonsattel grade 2 and Vonsattel grade 4 HD tissue, n = 6 control, n = 4 HD with Vonsattel 2 tissue grade and 4 HD with Vonsattel 4 tissue grade. One-way ANOVA P = 0.0058; Tukey’s multiple comparisons test, control versus HD2 P = 0.0474; control versus HD4 P = 0.0061; HD2 versus HD4 P = 0.537.

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