Oral insulin was formulated into 2 g pieces of sugar-free chocolate. Baboons were fasted overnight (16 h) and given a single dosage (0, 1, 2, 5 or 10 IU kg –1 ) of oral insulin. BG measurements were collected at 0, 0.25, 0.50, 0.75, 1.00, 1.50 and 2.00 h time points. ITT AUC was observed to be reduced with 10 IU kg –1 QD-INS treatment. Baseline normalization of starting BG also demonstrated reductions in BG. The maximum percentage reduction in blood sugar was observed to be 0%, 5%, 10% and 13% for 1, 2, 5 and 10 IU kg –1 , respectively.
