Effect–effect plot of clinically defined migraine (n case/control = 74,495/1,259,808) vs. self-reported BRH (n case/control = 51,803/123,732) effects for 42 lead variants identified in this study (excluding high-impact variants in PRRT2 and A3GALT2; see Supplementary Table 7 for their associations with the respective phenotypes). Effects are from meta-analyses using a fixed-effects inverse-variance method based on effect estimates and s.e. under the additive model, in which each dataset was assumed to have a common OR but allowed to have different population frequencies for alleles and genotypes. The x axis and the y axis show the logarithmic estimated ORs for the associations with the respective phenotypes. Error bars represent 95% CI. The dashed red lines represent slope (s.d.) based on a simple linear regression through the origin using 1/s.e. as weights. Cohort descriptions are in Supplementary Table 1. Variants are colored according to their primary associations in this study. The red dot outlier depicts the variant rs72854118-G near KCNK5, its effects on BRH exceeding its effects on all migraine. Pheno, phenotype; Migr, migraine.
