The graph shows data for migraine (n case/control = 74,495/1,259,808), MA (n case/control = 16,603/1,336,517), MO (n case/control = 11,718/1,330,747), VD (n case/control = 30,297/86,134) and BRH (n case/control = 51,803/123,732). See Supplementary Table 1 for n case/control for each cohort. On the x axis, variants are plotted along the 22 autosomes and the X chromosome. On the y axis is the statistical significance of their association with the respective phenotypes from meta-analyses using a fixed-effects inverse-variance method based on effect estimates and s.e. under the additive model, in which each dataset was assumed to have a common OR but allowed to have different population frequencies for alleles and genotypes. Gray dots are not significant variants. Variant associations that reach the P threshold weighted by variant annotation 21 are represented by color-coded dots. Adjacent chromosomes are presented in different shades of gray. Known migraine loci are represented by gene names in black text, and new loci are represented by gene names in blue text.
