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Uptake of 14 C-INS alone, in conjugation with QD-INS or QD-INS–CS/GS or after QD-INS–CS/GS release was examined in cultured hepatocytes following a 2-h incubation at 37 °C. Oleic acid was used as a positive control of cellular uptake and activity. Insulin uptake was increased by attachment to QD.
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