Bar plots of the AUPRC for OOR state detection with different types of perturbation on the same OOR cell state, colored according to reference design. The rightmost plot shows the AUPRC for the detection of the shifted OOR cell state, excluding the fixed removed state. The height of the bar denotes the AUPRC computed on real data. The error bars indicate the 95% confidence interval (CI) calculated from bootstrapping with 1,000 resampling iterations. Cases where the CR design outperformed the ACR design when only the OOR state is removed are highlighted by the red dashed rectangles. In all box plots, the center line denotes the median; the box limits denote the first and third quartiles; and the whiskers denote 1.5× the interquartile range (IQR).
