Bubble Plot from Scientific Research

Heritability enrichment scores of signatures comprising genes significantly modulated by perturbations (rows) across human traits (columns), computed using sc-linker 55 . pos indicates the set of genes whose expression changes in the same direction as the perturbed gene (that is, downregulated by the perturbation), with the opposite applying to neg. Displayed are all perturbation signatures and traits with at least two significant ( P < 0.001) effects. Non-significant scores are grayed out. Bar plot: probability of loss-of-function intolerance 54 (pLI) of the corresponding perturbed gene.

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