Heatmap from Scientific Research

Heat maps of the top effect sizes (inferred with FR-Perturb) from the conventional screen (left), with the same effect sizes shown for the cell-pooled screen (middle) and one equivalent channel of the conventional screen (right). x axis: top 50 perturbed genes, based on their average magnitude of effect on all 17,552 downstream genes. y axis: top 2,000 downstream genes, based on the average magnitude of effects of all 598 perturbed genes acting on them. Rows and columns are clustered based on hierarchical clustering in the leftmost plot. For the left plot, all effects with FDR q > 0.2 are whited out (q value threshold relaxed to 0.5 for the middle and right plots).

DOI